4,908 research outputs found
Maternal vitamin D deficiency associated with neonatal hypocalcaemic convulsions
Maternal vitamin D insufficiency is not uncommon. Infants born to mothers who are deficient in vitamin D and or calcium, usually due to cultural modifications in their diets or clothing habits, and in addition are breastfed, are at risk of developing vitamin D deficiency and hypocalcaemia. We present a case of neonatal hypocalcaemic seizures secondary to vitamin D deficiency
Mother Positivity and Family Adjustment in Households with Children with a Serious Disability
Only limited attention has been given to parent coping resources in the positive adjustment of families of children with a disability. This study is the first to explore maternal positivity as a psychological coping resource related to family adjustment in these families. Consistent with broaden-and-build theory and prior positivity research, positivity was operationalized through a ratio of positive to negative affect scores. We employed longitudinal tracking over a 1 year interval. Children’s diagnostic categories included developmental conditions or impairments, mental health disorders, complex health conditions, physical/motor conditions or impairments, sensory impairments, and provisionally diagnosed conditions or impairments. We used a computer assisted telephone survey to gather psychological, family, and demographic information from 152 mothers in Alberta, Canada. Hierarchical regression analysis indicated mothers’ level of positivity and age, when controlled for family adjustment at Time 1, accounted for 46% of the variance in family adjustment at Time 2. That is, older mothers with higher positivity scores were found to live in households with higher levels of family adjustment after 1 year. These findings provide promising support for broaden-and-build theory, which posits that positive experienced emotions can offset and diminish the negative health and relationship impacts of chronic stress. Study findings support the salience of mothers’ positivity as a psychological coping resource, which is related to enhanced family adjustment in situations of childhood disability
De Sitter ground state of scalar-tensor gravity and its primordial perturbation
Scalar-tensor gravity is one of the most competitive gravity theory to
Einstein's relativity. We reconstruct the exact de Sitter solution in
scalar-tensor gravity, in which the non-minimal coupling scalar is rolling
along the potential. This solution may have some relation to the early
inflation and present acceleration of the universe. We investigated its
primordial quantum perturbation around the adiabatic vacuum. We put forward for
the first time that exact de Sitter generates non-exactly scale invariant
perturbations. In the conformal coupling case, this model predicts that the
tensor mode of the perturbation (gravity wave) is strongly depressed.Comment: 9 page
PrIC3: Property Directed Reachability for MDPs
IC3 has been a leap forward in symbolic model checking. This paper proposes
PrIC3 (pronounced pricy-three), a conservative extension of IC3 to symbolic
model checking of MDPs. Our main focus is to develop the theory underlying
PrIC3. Alongside, we present a first implementation of PrIC3 including the key
ingredients from IC3 such as generalization, repushing, and propagation
Equivalent forms of Dirac equations in curved spacetimes and generalized de Broglie relations
One may ask whether the relations between energy and frequency and between
momentum and wave vector, introduced for matter waves by de Broglie, are
rigorously valid in the presence of gravity. In this paper, we show this to be
true for Dirac equations in a background of gravitational and electromagnetic
fields. We first transform any Dirac equation into an equivalent canonical
form, sometimes used in particular cases to solve Dirac equations in a curved
spacetime. This canonical form is needed to apply the Whitham Lagrangian
method. The latter method, unlike the WKB method, places no restriction on the
magnitude of Planck's constant to obtain wave packets, and furthermore
preserves the symmetries of the Dirac Lagrangian. We show using canonical Dirac
fields in a curved spacetime, that the probability current has a Gordon
decomposition into a convection current and a spin current, and that the spin
current vanishes in the Whitham approximation, which explains the negligible
effect of spin on wave packet solutions, independent of the size of Planck's
constant. We further discuss the classical-quantum correspondence in a curved
spacetime based on both Lagrangian and Hamiltonian formulations of the Whitham
equations. We show that the generalized de Broglie relations in a curved
spacetime are a direct consequence of Whitham's Lagrangian method, and not just
a physical hypothesis as introduced by Einstein and de Broglie, and by many
quantum mechanics textbooks.Comment: PDF, 32 pages in referee format. Added significant material on
canonical forms of Dirac equations. Simplified Theorem 1 for normal Dirac
equations. Added section on Gordon decomposition of the probability current.
Encapsulated main results in the statement of Theorem
[89Zr]Oxinate4 for long-term in vivo cell tracking by positron emission tomography
Purpose 111In (typically as [111In]oxinate3) is a gold standard
radiolabel for cell tracking in humans by scintigraphy. A long
half-life positron-emitting radiolabel to serve the same purpose
using positron emission tomography (PET) has long
been sought. We aimed to develop an 89Zr PET tracer for cell
labelling and compare it with [111In]oxinate3 single photon
emission computed tomography (SPECT).
Methods [89Zr]Oxinate4 was synthesised and its uptake and
efflux were measured in vitro in three cell lines and in human
leukocytes. The in vivo biodistribution of eGFP-5T33 murine
myeloma cells labelled using [89Zr]oxinate4 or [111In]oxinate3
was monitored for up to 14 days. 89Zr retention by living
radiolabelled eGFP-positive cells in vivo was monitored by
FACS sorting of liver, spleen and bone marrow cells followed
by gamma counting.
Results Zr labelling was effective in all cell types with yields
comparable with 111In labelling. Retention of 89Zr in cells
in vitro after 24 h was significantly better (range 71 to
>90 %) than 111In (43–52 %). eGFP-5T33 cells in vivo
showed the same early biodistribution whether labelled with
111In or 89Zr (initial pulmonary accumulation followed by
migration to liver, spleen and bone marrow), but later translocation
of radioactivity to kidneys was much greater for 111In.
In liver, spleen and bone marrow at least 92 % of 89Zr
remained associated with eGFP-positive cells after 7 days
in vivo.
Conclusion [89Zr]Oxinate4 offers a potential solution to the
emerging need for a long half-life PET tracer for cell tracking
in vivo and deserves further evaluation of its effects on survival
and behaviour of different cell types
The roles of transparency and trust in the relationship between corruption and citizen satisfaction
Reducing corruption and improving citizen satisfaction are important aims of government, yet the link between these two policy aims has rarely been explored. This article reports a study into the roles played by transparency and trust in the relationship between governmental corruption and citizen satisfaction with public services. The study was based on data gathered in South Korea to evaluate a specific initiative that had sought to reduce corruption and increase citizen satisfaction with public works programmes. The data indicated that the relationship between corruption and satisfaction was moderated by transparency and partially mediated by trust.
Points for practitioners:
The study sheds light on the roles of transparency and trust in the relationship between corruption and citizen satisfaction with public services, and thus provides insights for developing policy aimed at curtailing corruption and improving satisfaction
Are parents identifying positive aspects to parenting their child with an intellectual disability or are they just coping? A qualitative exploration
Although acknowledging the stress of raising their child with intellectual disabilities, parents also report that their child has brought about many positive changes in themselves and family. This study reports what parents perceive to be a positive aspect of parenting their child, as currently what constitutes a ‘positive’ is unclear. Seven key themes were identified; an increased sense of personal strength and confidence, changed priorities, greater appreciation of life, pleasure in the child’s accomplishments, increased faith/spirituality, more meaningful relationships and the positive effect that the child has on the wider community. Interpretive examination of the themes reveals that the positive aspects identified consist mostly of meaning-focused coping strategies. These enable parents to adapt successfully to the stressful experiences of raising their child and therefore could be amenable to meaning-focused therapeutic interventions for parents with newly diagnosed children or for those unable to identify any positive aspects of parenting their child
Investigating Unique Environmental Contributions to the Neural Representation of Written Words: A Monozygotic Twin Study
The visual word form area (VWFA) is a region of left inferior occipitotemporal cortex that is critically involved in visual word recognition. Previous studies have investigated whether and how experience shapes the functional characteristics of VWFA by comparing neural response magnitude in response to words and nonwords. Conflicting results have been obtained, however, perhaps because response magnitude can be influenced by other factors such as attention. In this study, we measured neural activity in monozygotic twins, using functional magnetic resonance imaging. This allowed us to quantify differences in unique environmental contributions to neural activation evoked by words, pseudowords, consonant strings, and false fonts in the VWFA and striate cortex. The results demonstrate significantly greater effects of unique environment in the word and pseudoword conditions compared to the consonant string and false font conditions both in VWFA and in left striate cortex. These findings provide direct evidence for environmental contributions to the neural architecture for reading, and suggest that learning phonology and/or orthographic patterns plays the biggest role in shaping that architecture
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